Welcome to the Journal of Immunological Sciences

Manuscript Guidelines

The journal has specific rules to formatting a manuscript that authors should adhere to before shipping their manuscript. These guidelines are primarily intended to make the submission of manuscript quick and easy.    Read More

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Ethics & Disclosures

Journal of Immunological Sciences is primarily based on values centered on loyalty, commitment, scientific accuracy, and ethics. It has adopted clear and rigorous ethical guidelines for best working practices.    Read More

What happens next to your Submission

Each article we publish benefits from hundreds of hours of work by Chief editors, Sectional editors, Reviewers, Manuscript editors, Proofreaders, Graphics and Web experts, who work to ensure that the manuscript meets our standards.    Read More


Focus & Scope

Journal of Immunological Sciences is a multidisciplinary, open access, peer reviewed, non-profit journal, that publishes papers of the highest quality and significance in all areas of immunology. It aims at playing an essential role in monitoring advances in the various fields of immunology, bringing together the results in a readable and lucid form. It publishes high-impact, cutting-edge research papers for immunologists, physicians and researchers interested in immunology. It provides a novel way to disseminate the latest findings in basic and translational research in Immunology and to facilitate communication, both among scientists as well as the community at large.

The Journal of Immunological Sciences welcomes submissions that explore novel ideas and approaches, as long as they are underpinned by conventional scientific practice and present falsifiable hypothesis that are tested with empirical methods and evidences.

This journal publishes research articles relevant to (but not limited) immune system and its molecular, functional, histological, developmental, cellular aspects.

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Recent Articles

Vol 2-6 Commentary

Immune Thrombocytopenia: Antiplatelet Autoantibodies Inhibit Proplatelet Formation by Megakaryocytes and Impair Platelet Production in vitro

José Perdomo

Haematology Research Unit, St George and Sutherland Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia

DOI: 10.29245/2578-3009/2018/6.1163 View / Download Pdf View Full Text
Vol 2-6 Commentary

Commentary: "Interference of Doxycycline Pretreatment in a Model of Abdominal Aortic Aneurysms"

Karina M. Mata1*, Cleverson R. Fernandes1, Cristiane Tefé-Silva2, Simone G. Ramos1

1Department of Pathology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil

2University Center of Barão de Mauá, Ribeirão Preto, SP, Brazil

Abdominal aortic aneurysm (AAA) represents a complex pathophysiological process of weakening and dilatation of the aortic wall associated with atherosclerosis, chronic inflammatory response and hemodynamic alterations. Degradation of the extracellular matrix by the matrix metalloproteinases (MMPs) and an imbalance between MMPs and their tissue inhibitors (TIMPs), have fundamental roles in the development of AAA. However, the exact pathogenetic mechanisms remain incompletely elucidated. In addition to the previous results already published “Interference of doxycycline pretreatment in a model of abdominal aortic aneurysms”, in this commentary we have complementary results. Here we have included new findings of the TIMPs 1 and 2 expressions in animals submitted to AAA surgical induction associated with doxycycline pretreatment. In this study, we used a new experimental model, developed in our laboratory, to induce AAA by combining two potential causes of MMP secretion: inflammation and turbulent blood flow. Male Wistar rats were divided into Control (C), Control+ Doxycycline (C+D), Aneurysms (A) and Aneurysms+Doxycycline (A+D) groups. The rats were euthanized at 3, 7 or 15 days post-surgery (dps). The administrated doxycycline started 48 hours before the surgical induction of AAA until the end of the experiment. After 1, 3, 7, and 15 dps, the animals were euthanized under anesthesia and the vessels were collected to measurement of TIMPs 1 and 2 by western blot. Our results demonstrate an increased expression of TIMPs 1 and 2 in aneurysm group (A) probably in an attempt to counteract the increased activity of MMPs 2 and 9. In aneurysms groups submitted to doxycycline pretreatment (A+D) showed the regulation of expression of TIMP 1 and 2, remaining close to baseline levels from the third day, similar to expression found the control groups (C and C + D). This study suggests that the pretreatment with doxycycline balances the TIMPs 1 and 2 expressions with a protective effect on the progression of abdominal aortic aneurysms in experimental model.

DOI: 10.29245/2578-3009/2018/6.1155 View / Download Pdf View Full Text
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